Rapid Detection of TNT Metabolites in Human Body Achieved through New Technology

A research group led by Prof. Huang Chaoqun from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences has developed a new dual drift tube ion mobility spectrometry (DDT-IMS) technology that allows for the rapid detection of toxic metabolites from TNT. The technology is able to detect both positive and negative ions of four metabolites, providing valuable health warnings by detecting residual metabolites in the human body. These metabolites, derived from TNT biodegradation, pose potential health risks, especially for workers in TNT manufacturing facilities. The research results were published in Talanta, showcasing the efficacy of the DDT-IMS technology in detecting these metabolites in urine samples. The study evaluated the ion mobilities of the metabolites and assessed the impact of drift tube temperature on the results. The research team demonstrated the feasibility and effectiveness of DDT-IMS in detecting TNT metabolites within complex biological matrices, highlighting its potential in assessing environmental and biological risks associated with TNT. This innovative technology shows promise in improving health and safety measures for individuals exposed to TNT and its metabolites.

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